COMPREHENSIVE REVIEWOF GRUHADHUMA TAILA NASYA (NASAL DROP): A REMEDY FOR NASA ARSHA (NASAL POLYPOSIS)

Abstract

Gruhadhuma Taila (GT) is herbo-mineral oil indicated for Nasa arsha (nasal polyposis) which has an impact on health-related quality of life (HRQL). GT consists of seven ingredients viz. Gruhadhuma, Piperlongum Linn., Cedrusdeodare (Roxb.) Loud., Yavakshara, Hordeum vulgare Linn., PongamiapinnataMerr.,Saindhavalavana and Achyranthes aspera Linn.Objective of the study is to review the Rasadipancaka, phytochemistry and bio activities exerted by the ingredients of Gruhadhuma Taila to find the effectiveness theoretically. Data were composed from authentic Ayurveda, Modern and Traditional medicinal texts and authentic electronic databases as Google scholar, PubMed and MEDLINE. Retrieved data were tabulated and analysed by percentage by SPSS version 19.The ingredients of GT are responsible for pacifying vitiated Kaphadosha by Katu rasa (pungent) (38.5%), Ushnavirya (hot potency) (71.5%) and Katuvipaka(post digestion effect) (62.5%). Vishada (non - slimy) and Sara (mobile) guna are 5% each which are responsible for the potency of the drug.The herbal ingredients ofGT has important Ayurveda pharmacological properties as Rasayana (rejuvenation), Arshoghna(cure piles)and Vishaghna (anti toxic/antidote).Further the study revealed the presence of important secondary metabolites such as sesquiterpenes, tannins, phytosterols, phenol compounds and flavonoids which significantly reduce Nasa arsha. Further ingredients consist of bioactivities as anti-bacterial, anti-microbial and anti-tumour actions responsible for early clinical remission. Thus, GT is logically proved for the efficacy considering the pharmacodynamic and pharmacological attributes which should be clinically validated with large sample randomized control trials.