EXPERIMENTAL EVALUATION OF ANTI DIABETIC ACTIVITY OF SWARNAMAKSHIKA BHASMA

Abstract

Swarnamakshika identified under Maharasa Varga is considered as Chalcopyrite Mineral which contains iron (Fe), Copper (Cu) and Sulphur(S) as major components along with other trace elements of therapeutic importance. Swarnamakshika possess Rasayanagrya, Dusadhya Rogahara, Sakalamayaghna and Mehahara properties. Present research work has been taken to evaluate anti-diabetic activity of Swarnamakshika Bhasma (SMB) on Albino rats.Five groups viz Normal Control, Diabetic Control, Glibenclamide (GLB, 10mg/kg, p.o.) SMB (0.45mg/0.2kg ,p.o) and SMB+Honey (0.9mg/0.2kg ,p.o) containing 6 rats in each group are subjected for Acute (i.e. single day) and chronic (15days) anti-diabetic study on Alloxan (ALX) induced diabetic rats and compared statically by Anova Test. Blood Glucose level of the drug was evaluated by Oral Glucose tolerance test (1stDay), and Fasting Blood Glucose Estimation (1,3,5,7,9,11,13,15-Days ) for evaluation of Anti- Diabetic activity. Re-sults showed that SMB and SMB+HONEY possess significant anti-hyperglycemic activity. Histo-pathological Studies showed that SMB has regenerated islets of langerhanns, and rela-tively increased granulated and normal β-cells of pancreas.