ASSESSMENT OF NEPHROPROTECTIVE ACTIVITY OF TRAIKANTAKA GHRITA ON WISTAR ALBINO RATS

Abstract

The present study was aimed to evaluate nephroprotective activity of Traikantaka Ghrita(TG) , A Polyherbal Formulation against gentamicin induced experimental animal models.TG is a combination of herbs and shilajatu which possess mutrakrichra hara, ashmari hara and mutrala properties. Nephrotoxicity was induced in wistar albino rats by intraperitoneal administration of gentamicin(80mg/kg).Effect of simultaneous administration of TG in different doses by oral was estimated. Serum creatinine, serum urea and blood urea level as renal markers,body weight % and Lipid peroxidation, Glutathioneperoxidase, Catalase activity as antioxidant parameters. .Histopathological study of the rats was carried out. From the study, it was revealed that Traikantaka Ghrita Moderately prevent renal damage by normalizing increased levels of renal markers. From the present study, it was concluded that Traikantaka Ghrita. possess nephroprotective activity in experimental animals.