A CONCEPTUAL STUDY OF AGAD YOGA AS PROBABLE ANTIVIRAL MEDICINE FOR COVID-19

Abstract

The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak affected the whole world on December 2019 and resulted in a major health crisis. The transmission and mortality rate of COVID-19 appear more severe and uncontrollable and new variants still affecting the population despite being vaccinated. The major complications of COVID-19 are respiratory failure and cardiovascular diseases. Several therapeutic management were put forward but till date there are no specific treatment or medicine developed for this viral infection. The present review summarized the Ayurveda agad yoga mentioned in Charak samhita, Sushrut samhita,Aashtanga samgraha, Ashtanga hridaya emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus. Plant-derived phytochemicals have already been reported to prevent the viral infection by inhibiting the viral replications or terminating their cell life cycle. In this review, we explored 11 Agad yoga which are indicated in jwar(fever), kasa(cough), swasha(difficulty in breathing) and janapadodhwamsa vyadhi(epidemic disease) entioned in Charak samhita, Sushrut samhita, Ashtanga samgraha and Ashtanga hridaya and summarized the mechanistic approaches of their contents as antiviral activity. Reports on the antiviral activity of the contents of agad yoga belong to the can be explored for the development of safe and efficacious products targeting COVID-19.