• Rajendra Kumar PhD Scholar
  • Ashok Kumar Associate Professor
  • Gaurav Bilwal Pharmacologist
  • Narinder Singh Associate Professor
  • P. Hemantha Kumar Professor & Head PG Dept. of Shalya Tantra, National Institute of Ayurveda (Deemed to be University) Jaipur


Urolithiasis, Experimental Rat Models, Renal Stone Induction


Urolithiasis or renal calculus disease is most common disorder of human excretory system in which solid concretion of mineral salts are found in any part of the urinary tract from kidney to urethra. Various theories are proposed to explain the mechanism behind development of the renal stone disease but still the exact aetiology of the disease remains unclear. Although major technological advances have been made in the last few decades for the surgical management of the urolithiasis, yet little progress has been seen for conservative management and prevention of recurrence of disease. Traditionally the disease has been studied in human beings through assessment of urine, serum and adoption of imaging modalities to scan the body for detection of stone. In order to understand its aetiology in better way and develop modalities for its conservative management and prevention of recurrence, an urgent requirement was felt to develop valid and reliable animal experimental models. Variety of animal models have been developed to understand the pathophysiology of the disease and assess the efficacy of various treatment modalities for the management and prevention of the disease. Among these animal models, rodents are more commonly used in animal experiments, particularly rats and mice due to their availability, size, low cost, ease of handling and fast reproduction rate. As these rat models are hope of developing breakthrough intervention for the prevention and management of renal stone disease, this review article attempts to summarise all types of experimental rat models along with methods of their handling and induction of renal stones.


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How to Cite

Rajendra Kumar, Ashok Kumar, Gaurav Bilwal, Narinder Singh, & P. Hemantha Kumar. (2021). REVIEW ARTICLE ON EXPERIMENTAL RAT MODELS FOR RENAL STONE DISEASE. International Journal of Applied Ayurved Research, 5(2), 79–89. Retrieved from



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