THE EFFICACY OF BOREVIA DIFFUSAEXTRACT IN CHRONIC RENAL FAILURE PATIENTS UNDERGOING HEAMODIALYSIS

Abstract

The present medicinal system is dominated by the Alopathy or western medicine which is still evolving and during last few decades focus was based on chemical origin of most of the medicines .Thus majority of drugs in current practice are from synthetic origin Even so, a large number of the synthetic molecules are based directly or indirectly on natural products. Chronic Renal failure (CRF) represents a progressive irreversible decline in the glomerular filtration rate (GFR).A common phenomenon in renal failure is progressive renal function loss irrespective of the underlying cause of the kidney disease .The underlying cause of CRF has shifted from classic causes such as glomerulo nephritis and interstitial nephritis, Atherosclerosis ,hypertensive nephropathy and diabetic nephropathy. Most common screening test for CRF is the measurement of serum creatinine. However, it a insensitive measure, sinceasmuchas 50% of the nephron mass may be lost before creatinine concentration increases and levels are influenced by several factors such as sex, age, body mass and diet. Chronic renal failure refers to an irreversible deterioration in renal function It classically develops over a period of years, initially it manifests only a biochemical abnormality. Eventually loss of excretory, metabolic & endocrine functions of the kidney leads to the development of clinical symptoms & signs of renal failure which refers to uremia, when death is likely without renal replacement therapy it is called as End Stage Renal Disease(ESRD).